©2019 by ASEAN DxD Initiative

Annex A

Target Product Profile (TPP) on Specifications for Unmet Needs in Malaria, Dengue, Hep B & TB

  1. Malaria TPP:

  2. Dengue TPP:

    • Lateral flow point-of-care (POC) detection of NS1 for early fever (1st 5 days onset)

    • Lateral flow POC for IgG and IgM after 5 days of 1st onset

    • PCR based test for dengue serotypes for surveillance

    • Diagnostics for secondary infection to identify suitable vaccine

    • Further TPP info: https://www.who.int/tdr/publications/documents/dengue-diagnosis.pdf

  3. Hepatitis B TPP:

  4. TB TPP:

    • Rapid point-of-care non-sputum-based test capable of detecting all forms of TB by identifying characteristic biomarkers or biosignatures

    • Rapid triage TB test which is point-of-care that should be a simple, low-cost test that can be used by first-contact health-care providers to identify those who need further testing

    • Rapid test for drug susceptibility that can be used at the microscopy-centre level of the health-care system to select first-line regimen-based therapy (the rapid DST test). The following anti-TB agents should be included in resistance testing at the microscopy level (they are presented in order of decreasing priority): 

      • rifampicin 

      • fluoroquinolones (including moxifloxacin)

      • isoniazid and pyrazinamide

    • Further TPP: https://www.who.int/tb/publications/tpp_report/en/

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